I have the Domke F-5XB and while it is a good little bag, it can really only hold the Canon EOS 20D (w/ lens) plus one other lens. I used this bag throughout a 3-week trip to Asia and it performed fine. The zipper didn't bother me at all. The teeth are large and plastic and don't catch on anything or scratch anything up.

However.. often times you need to carry more than one extra lens. To fulfil this need I picked up the Domke F-803. I wanted a bag that could carry the 20D w/ 1 lens attached, 2 extra lenses, and a few titbits like lens caps and maps. I also wanted a bag that didn't look like a camera bag.

The Domke F-803 fulfils this role quite well, IMO. I ordered one in the 'sand' colour to disguise the bag's role a bit further (black bags still scream 'camera' to me - especially the black shoulder straps).

The 70-300 DO sits at the bottom of the main compartment, with a couple padded spacers on the sides (gleaned from other camera bags/lens cases):

Plus the clasp isn't the classic plastic prong-type found on most camera bags, it's a metal hook-style clasp. This is both a blessing and a curse. It makes the bag very secure when closed, but it means you need two hands to open it.

Most of the time, however, I leave it unhooked. To give the bag a fastener without the hook, I cut off the flaps to the two pockets (don't really need these as the pockets are quite deep) and had an alteration shop sew the velcro from them on to the main flap of the bag (I can't sew to save my life). This gives the main flap a good velcro fastener.

Ironically, most times I don't even want the velcro because I like being able to slip the camera in and out one-handed, so I recently slapped some duct tape over the velcro :).

Few last titbits: the strap is a nice beige colour (avoid those black straps!) and it has some rubber threads sewn into it which makes it much grippier than your average strap without needing the tell-tale shoulder pad built into the strap. The handle is also pretty good.. feels very sturdy.

The only downsides I find with this bag are that it doesn't always stand completely upright (probably due to the way I have the lenses arranged internally) and it'd be nice if the metal clasp was easier to un-do

thanks to edaly  for photos & info.

Review #2

Exterior dimensions are within ~1/4" of the dimensions shown (canvas is not that thick). Bag is nicely soft and not over padded. I find it more than enough protection. Of course, if you drive over it or get hit by a truck, no bag is going to be enough protection.

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This front of the F-803. Brass "latch" is my alteration...which was easy....brass or metal ring about 1 1/4" round and latch. Originally, with my thick fingers, I found this easier than standard...but my other Domkes I have not changed...I got use to them after a little usage.  

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As you can see, it has a rather slim profile...which is what makes it attractive, to me. With nothing in front pockets it is just about 4", as "advertised". side to side is 13"

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This was just to emphasis the front pockets. Those are IBM cards for size reference.

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That is a 'PC Photo' Mag (8.5" x 11")in the back pocket

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The inside...comes standard with the single sleeve. Light padding down sides and across bottom. (sorry for the OOF)

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Simple quick travel set. Canon EF-S 17-85mm f/4-5.6 IS USM on Canon EOS 20D with 70-300 DO in sleeve.

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Just to show that a larger lens can fit. This is a Canon EF 24-70mm f/2.8L USM.

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Here is what was in bag in prior picture. 17-85 (3.6") is just there to show size delta with 24-70 2.8 (5").

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There is sufficient depth to carry add'l lenses if you need to. Here I have a 10-22 and 50 1.8 in the bottom. White rectangle on right is foam pad from sleeve (see next image)

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To protect the bottom lenses, I use the foam separator, which I took out of the sleeve (I just use the sleeve padding on the sides, take out front & back to reduce bulk...the canvas provides sufficient padding)

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...and then camera easily fits on top. I went all over Paris and across Italy for 3 weeks with this config. It worked very well and I never had any concern. The back really just looks like a business satchel....though I, of course, looked like a tourist.

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Lots of add'l storage in two front packets. On the left is a Canon 580EX Speedlite flash, which fits flush with top of pocket. Other pocket, I keep add'l batteries, or whatever. CD cards, I usually keep in front zippered pockets on flap.

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Here is all the gear that was in bag in prior picture.

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I modified the latch as I found the standard Domke latch easy to snap closed but a little difficult to open...which meant I had a tendency to not use it....which leaves one open to many problems. This fix was easy and I found both pieces at Ace Hardware. The brass thumb latch is 3" total length. The split ring is 15/16", but a little larger would be ok. Actually the ring was more than the latch, so if aesthetics don't both you, a steel ring could be used. I cut off the old latch with a Dremel tool (any metal cutter will work, but Dremel is the lazy man's way. Put the ring on the latch. Then get the ring around the webbing (a needle nose plier will help). Voila! easy open, very easy close...at least for me. Oh...you also need to shorten the strap as much as you can as the latch is a little longer than the standard one

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This is the standard Domke latch 9from another bag). It is not difficult to use, at all. Just for my "walk around" bag, I found the thumb latch easier.

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I was asked if a Canon EF 70-200 f/2.8L IS USM would fit. The best config, in my view, is shown above, with the camera vertical. This provides ample length ~8", which is more than enough for even a 70-200 2.8. The strap might have to be adjusted a little longer and there is sufficient length to do that. You need to get an add'l single sleeve, image of which I show later.

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For those who may want just a little bigger. This compares to the F-803 which is 13" x 4" x 9"

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Add'l sleeve if you want to orient camera vertical for longer length lenses. It is currently $12.95 at B&H Photo.

Thanks to jrschwaller for photos and info

Review #3

Photo contains:

Canon EOS 20D

EF 70-200
Canon EF 50mm f/1.8II

Canon 580EX Speedlite
 Manuals , Filters, Cards, Cords ,etc
 Canon EF-S 17-85mm f/4-5.6 IS USM or Canon EF-S 10-22mm f/3.5-4.5 USM or EF 85
1.8
 Kenko 1.4 TC
 Kenko Extension Tubes

Here is another picture with front compartments folded open.

I do have a padded piece that sits along the top of my flash to protect it and the camera from scratching each other.

Thanks to BearLeeAlive for photos and info